化合物简介
rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective thaninjectable interferon beta 1a (Rebif®).
基本信息
中文名称
2-氰基-3-羟基-N-[4-(三氟甲基)苯基]-2-丁烯酰胺
英文名称
2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide
中文别名
特立氟胺
英文别名
2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide、2-Cyano-3-hydroxy-N-(4-trifluoromethylphenyl)crotonamide、Teriflunomide、2-Butenamide (2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]
CAS号
108605-62-5
分子式
C12H9F3N2O2
分子量
270.207
精确质量
270.062
PSA
73.12
LOGP
3.07248
物化性质
外观与性状
白色固体
密度
1.424 g/cm3
沸点
410.8ºC at 760 mmHg
闪点
202.3ºC
折射率
1.551
蒸汽压
6.63E-06mmHg at 25°C
