化合物简介
Fosamprenavir (marketed by ViiV Healthcare as the calcium salt under the trade names Lexiva in the U.S. and Telzir in Europe) is a drug for the treatment of HIV infections. It is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. The FDA approved it October 20, 2003, while the EMA approved it on July 12, 2004. The human body metabolizes fosamprenavir in order to form amprenavir, which is the active ingredient. That metabolization increases the duration that amprenavir is available, making fosamprenavir a slow-release version of amprenavir and thus reducing the number of pills required versus standard amprenavir.
基本信息
中文名称
福沙那伟钙
英文名称
Fosamprenavir calcium
中文别名
福沙那韦钙、[(3S)-氧杂环戊-3-基] N-[(2S,3R)-4-[(4-氨基苯基)磺酰-(2-甲基丙基)氨基]-1-苯基-3-磷酰氧基-丁烷-2-基]氨基甲酸酯钙盐
英文别名
calcium [(3s)-oxolan-3-yl] n-[(2s,3r)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate、Lexiva、Fosamprenavir Calcium Salt、[(2R,3S)-1-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[[(3S)-oxolan-3-yl]oxycarbonylamino]-4-phenyl-butan-2-yl]oxyphosphonic acid、Telzir
CAS号
226700-81-8
分子式
C25H34CaN3O9PS
分子量
623.669
精确质量
623.138
PSA
201.57
LOGP
5.4491
编号系统
UNII
ID1GU2627N
物化性质
外观与性状
白色微结晶针状
熔点
282-284ºC