化合物简介
Ataciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.
基本信息
中文名称
5-氯-2-(5-氯噻吩-2-磺酰基氨基)-N-(4-(吗啉-4-磺酰基)苯基)苯甲酰胺
英文名称
ataciguat
中文别名
英文别名
HMR 1766
CAS号
254877-67-3
分子式
C21H19Cl2N3O6S3
分子量
576.493
精确质量
574.981
PSA
166.88
LOGP
6.3744
物化性质
密度
1.613g/cm3
折射率
1.684