化合物简介
OSU-03012 (AR-12) is a celecoxib derivative with anticancer and anti-microbial activity. Unlike celecoxib, OSU-03012 does not inhibit COX, but inhibits several other important enzymes instead which may be useful in the treatment of some forms of cancer, while also having antifungal activity via disruption of phosphoinositide-dependent kinase-1 activity. When combined with PDE5 inhibitors such as sildenafil or tadalafil, OSU-03012 was found to show enhanced anti-tumour, antibiotic and antiviral activity against a wide variety of organisms, with this activity thought to be mediated via inhibition of the chaperone protein BiP.
基本信息
中文名称
2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺
英文名称
2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide
中文别名
达努塞替
英文别名
PDK1 inhibitor AR-12、2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide
CAS号
742112-33-0
分子式
C26H19F3N4O
分子量
460.45
精确质量
460.151
PSA
72.94
LOGP
6.535
编号系统
MDL号
MFCD12912272
物化性质
密度
1.369g/cm3
沸点
683.017ºC at 760 mmHg
闪点
366.876ºC
折射率
1.649