化合物简介
Rifabutin (Rfb) is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare.
基本信息
中文名称
利福布汀
英文名称
rifabutin
中文别名
利福布汀(安莎霉素)、利福布丁、螺哌啶利福霉素S
英文别名
Rifabutin、4-deoxo-3,4-[2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-rifamicin S、Rifabatin、RIFABUTINE、1\',4-didehydro-1-desoxi-1,4-di-hydro-5\'-(2-methyl-propyl)-1-oxo-rifamycin、6,9-dihydro-5,17,19,21-tetrahydroxy-8,9-[2-spiro-(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-23-methoxy-2,4,12,16,18,20,22-heptamethyl-6-oxo-2,7-epoxypentadeca-[1,11,13]-trienimine-2H-furo[2\',3\',7,8]nafto[1,2-d]imidazolo-2,4\'-piperidine-5,10,26. (3H,9H)-trione-16-acetate、lm427、Mycobutin、Ansamycin、Ansatipine、antibioticlm427
CAS号
72559-06-9
分子式
C46H62N4O11
分子量
847.005
精确质量
846.442
PSA
205.55
LOGP
4.6468
编号系统
UNII
1W306TDA6S
物化性质
外观与性状
红色-紫罗兰色结晶粉末
密度
1.339g/cm3
沸点
969.589ºC at 760 mmHg
熔点
169-171ºC
闪点
540.188ºC
折射率
1.623
储存条件
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
安全信息
海关编码
2941903000
