4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

CAS号：170660-46-5

英文名：4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

分子式：C33H33N3O7S

分子量：615.696

合成路线

3-[1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanyl]-propionitrile

3-[1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanyl]-propionitrile

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

1-[(3aR,4R,6R,6aR)-2,2-Dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione

1-[(3aR,4R,6R,6aR)-2,2-Dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

3-{1-[(3aR,4R,6R,6aR)-2,2-Dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanyl}-propionitrile

3-{1-[(3aR,4R,6R,6aR)-2,2-Dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanyl}-propionitrile

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

2,4,6-Triisopropyl-benzenesulfonic acid 1-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

2,4,6-Triisopropyl-benzenesulfonic acid 1-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl ester

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

4-S-(2-cyanoethyl)-5'-O-(4,4'-dimethoxytrityl)-4-thiouridine

上游原料

2,4,6-Triisopropyl-benzenesulfonic acid 1-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl ester 1-[(3aR,4R,6R,6aR)-2,2-Dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione 3-{1-[(3aR,4R,6R,6aR)-2,2-Dimethyl-6-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanyl}-propionitrile 3-[1-((2R,3R,4R,5R)-3,4-Bis-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-ylsulfanyl]-propionitrile

下游产品

4-S-(2-cyanoethyl)-2'-O-(tert-butyldimethylsilyl)-4-thiouridine 3',5'-bisphosphate tetrakis(2-cyanoethyl) ester 2′-O-(tert-butyldimethylsilyl)-4-(2-cyanoethylthio)uridine