化合物简介
2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor. It is an ester formed from the omega-6 fatty acid arachidonic acid and glycerol. It is present at relatively high levels in the central nervous system, with cannabinoid neuromodulatory effects. It has been found in maternal bovine and human milk. The chemical was first described in 1994-1995, although it had been discovered some time before that. The activities of Phospholipase C (PLC) and diacylglycerol lipase (DAGL) mediate its formation. 2-AG is synthesized from arachidonic acid-containing diacylglycerol (DAG).
基本信息
中文名称
2-花生酰基甘油
英文名称
2-arachidonoylglycerol
中文别名
英文别名
1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate、2-Arachidonyl Glycerol、2-Arachidonyl glycerol
CAS号
53847-30-6
分子式
C23H38O4
分子量
378.545
精确质量
378.277
PSA
66.76
LOGP
5.0285
编号系统
PubChem号
24891388
MDL号
MFCD01862600
物化性质
外观与性状
液体
密度
0.992 g/cm3
沸点
508.6ºC at 760 mmHg
闪点
2°C
折射率
1.507
储存条件
-20ºC
安全信息
安全说明
S26-S36/37
WGK Germany
2
危险类别码
R11
海关编码
2916190090
危险品运输编码
UN 1648 3/PG 2
危险品标志
Xn; F